Pathogenic Wiki
Master the microscopic war inside the human body. Builds, walkthroughs, organelle synergies, and expert guides for every Pathogen.
New to Pathogenic? Start Here
Pathogenic is a 2D roguelike twin-stick shooter where you play as a parasite grafting organelles onto your cell. These guides cover controls, your first run, and how to survive the immune system.
- How to Play Pathogenic – Beginner Guide Learn Pathogenic basics: movement, organelle grafting, room clearing, boss fights, and your first successful run through the human body. Read guide
- Keyboard and Mouse Controls – Pathogenic PC Guide Default Pathogenic PC controls: WASD movement, mouse aim, Space dodge, Tab editor, M map, and combat input tips. Read guide
- Plasmid Progression – Pathogenic Metagame Guide Complete guide to Pathogenic plasmid trees: earning fragments, pathogen-specific upgrades, unlock order, and demo transfer rules. Read guide
Popular Pathogenic Builds
Organelle combinations matter more than raw stats. Explore ranged artillery, melee Phagocytosis runs, minion swarms, and pathogen-specific setups that break the immune system.
- Ranged Artillery Build – Pathogenic Secretor Guide Read guide
- Melee Phagocytosis Build – Pathogenic Spike Guide Read guide
- Minion Swarm Build – Pathogenic Spore Guide Read guide
- Amoeba Flexible Build – Pathogenic Reshape Guide Read guide
- Nanobot Armor Build – Pathogenic Tank Guide Read guide
- Kite Ballistic Build – Pathogenic Flagella Guide Read guide
- Multi-Hit Melee Build – Tri-Phase & Gyrase Guide Read guide
Organ Walkthrough Hub
Each organ in Pathogenic has unique hazards, enemy pools, and boss fights. Plan your route through Skin, Intestine, Stomach, Liver, Lungs, Heart, and the hidden secret level.
- Skin Walkthrough – Pathogenic First Organ Guide Read guide
- Intestine Walkthrough – Pathogenic Maze Organ Guide Read guide
- Stomach Walkthrough – Pathogenic Acid Organ Guide Read guide
- Liver Walkthrough – Pathogenic Detox Organ Guide Read guide
- Lungs Walkthrough – Pathogenic Airflow Organ Guide Read guide
- Heart Walkthrough – Pathogenic Final Organ Guide Read guide
- Secret Organ Walkthrough – Pathogenic Hidden Level Guide Read guide
Organelle System Deep Dive
Over 120 organelles and mutations can be looted and grafted. Learn how Flagella, Mitochondria, Secretors, Spikes, Pseudopods, and Traits interact to create game-breaking synergies.
- Flagella Organelles – Pathogenic Movement Guide Read guide
- Mitochondria Organelles – Pathogenic Power Guide Read guide
- Secretors Organelles – Pathogenic Ranged Weapons Guide Read guide
- Spikes Organelles – Pathogenic Melee Weapons Guide Read guide
- Pseudopods Organelles – Pathogenic Auto-Attack Guide Read guide
- Organelle Traits – Pathogenic Passive Effects Guide Read guide
- Multi-Hit Organelles – Update 4 Weapon Guide Read guide
Choose Your Pathogen
Seven playable pathogens each offer different slot layouts and playstyles — from the shapeless Amoeba to the armor-stacking Nanobot. Compare unlock requirements and strengths.
- Pathogen Unlocks Guide – All 7 Playable Parasites How to unlock every Pathogenic pathogen: Bacteria, Helminth, Spore, Amoeba, Nanobot, Protozoa, Virus, and co-op Diatom requirements. Read guide
- Pathogen Tier List – Pathogenic Best Characters Ranked All seven Pathogenic pathogens ranked: Bacteria, Helminth, Spore, Amoeba, Nanobot, Protozoa, and Virus for clears and challenges. Read guide
- Amoeba Flexible Build – Pathogenic Reshape Guide Read guide
Challenge Modes & Antibiotics
Fifteen challenge modes rewrite the rules: melee-only Phagocytosis, room-rerolling Metamorphosis, timed Hyperplasia, and more. Antibiotics scale difficulty for daily runs.
Pathogenic Tools
Plan your next run with our interactive Build Planner. Slot organelles, preview synergies, and export a loadout before you infect your next host.
Is Pathogenic Worth It?
Our full Pathogenic review covers soft-body physics, build variety, organ biomes, challenge modes, co-op Diatom, and whether the $9.99 launch price delivers value.
Latest Pathogenic Updates
Post-launch patches add core chests, intestinal villi hazards, mid-run save-and-continue, Remote Play Together co-op, and Update 4 multi-hit organelles. Daily seeds still rotate with fifty percent random weapon starts.
Start with Remote Play Together co-op if you play Diatom online, read pathogen unlocks for all seven parasites, then explore multi-hit organelles and environmental hazards before pushing save-and-continue runs into Heart.
Pathogenic Wiki FAQ
What is Pathogenic?
Pathogenic is a 2D roguelike twin-stick shooter by Aberrant Labs and Slug Disco where you play as a parasite invading a human host. You loot and graft 120+ organelles to evolve your pathogen while fighting immune cells and rival parasites across procedurally generated organs.
When did Pathogenic release and on which platforms?
Pathogenic launched on Steam for PC on July 16, 2026 at a $9.99 base price. Console versions have not been announced at launch.
How many pathogens and organs are in the game?
There are seven playable pathogens—Bacteria, Helminth, Spore, Amoeba, Nanobot, Protozoa, and Virus—and six standard organs (Skin, Intestine, Stomach, Liver, Lungs, Heart) plus a hidden secret level.
What are the default PC controls?
WASD moves your pathogen, the mouse aims and fires, Space dodges, Tab opens the organelle editor, and M opens the fast-travel map. Full rebinding is available in Settings.
What is plasmid progression?
Plasmids are permanent upgrades earned from plasmid fragments collected during runs. Each pathogen has its own plasmid tree unlocking new organelles, stats, and challenge options between attempts.
Does the Steam demo progress transfer to the full game?
Yes. Plasmid progress from the demo carries over to the full release on the same Steam account.
What are Pathogenic challenge modes?
Fifteen challenge modes modify run rules. Examples include Phagocytosis (melee only), Metamorphosis (reroll organelles each room), Hyperplasia (timed runs), and Photosynthesis (no weapon organelles).
Is there multiplayer co-op?
Yes. Co-op Diatom supports online multiplayer where each player controls their own pathogen with scaled enemy difficulty and shared map discovery.
Is ppathogenic.wiki an official site?
No. ppathogenic.wiki is an independent fan wiki and is not affiliated with Aberrant Labs or Slug Disco. We compile guides, builds, and tools for the community.
Where can I buy Pathogenic?
Pathogenic is available on Steam. Search for Pathogenic by Aberrant Labs or visit the official Steam store page linked from our site header.